Maybe, maybe not...

My Toyota Camry lost 2 of the 4 cylinders. It did run rough, but
surprisingly nowhere near as bad as you'd think it would. It still
idled and I still managed to get a ticket for doing 80mph in a 55mph
zone. And even then it got way better than 6mpg.

I could pull the plug wires off of cylinders 2 and 4 and there was no
difference.

~jp